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Article

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.

The EMBO journal - 15 Nov 2001

Clerici M, Paciotti V, Baldo V, Romano M, Lucchini G, Longhese M P

Abstract excerpt

The evolutionarily conserved yeast Mec1 and Tel1 protein kinases, as well as the Mec1-interacting protein Ddc2, are involved in the DNA damage checkpoint response. We show that regulation of Tel1 and Ddc2-Mec1 activities is important to modulate both activation and termination of checkpoint-mediated cell cycle arrest. In fact, overproduction of either Tel1 or Ddc2 causes a prolonged cell cycle arrest and cell...

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Identifiers

PMID: 11707419
DOI: 10.1093/emboj/20.22.6485
PMCID: PMC125310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.PMID 11707419Read ↗

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