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Article

Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.

PLoS genetics - 1 Feb 2014

Bandhu Amitava, Kang John, Fukunaga Kenzo, Goto Greicy, Sugimoto Katsunori

Abstract excerpt

The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP ortholog) play a key role in DNA damage checkpoint responses in budding yeast. Previous studies have established the model in which Ddc1, a subunit of the checkpoint clamp, and Dpb11, related to TopBP1, activate Mec1 directly and control DNA damage checkpoint responses at G1 and G2/M. In this study, we show that Ddc2 contributes to Mec1 activation...

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Source

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Identifiers

PMID: 24586187
DOI: 10.1371/journal.pgen.1004136
PMCID: PMC3930518

Genes

ATR
ATRIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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