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Article

The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment.

Nucleic acids research - 15 Mar 2003

Nakada Daisuke, Shimomura Toshiyasu, Matsumoto Kunihiro, Sugimoto Katsunori

Abstract excerpt

MEC1 and TEL1 encode ATR- and ATM-related proteins in the budding yeast Saccharomyces cerevisiae, respectively. Phleomycin is an agent that catalyzes double-strand breaks in DNA. We show here that both Mec1 and Tel1 regulate the checkpoint response following phleomycin treatment. MEC1 is required for Rad53 phosphorylation and cell-cycle progression delay following phleomycin treatment in G1, S or G2/M phases. The...

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Identifiers

PMID: 12626713
DOI: 10.1093/nar/gkg252
PMCID: PMC152856

Genes

ATM
ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment.PMID 12626713Read ↗

Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast.Semantic proximity Read ↗

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant.Semantic proximity Read ↗

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Semantic proximity Read ↗

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.Semantic proximity Read ↗

A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Semantic proximity Read ↗

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Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Semantic proximity Read ↗

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