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Article

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.

Molecular and cellular biology - 1 May 2004

Baroni Enrico, Viscardi Valeria, Cartagena-Lirola Hugo, Lucchini Giovanna, Longhese Maria Pia

Abstract excerpt

DNA damage checkpoint pathways sense DNA lesions and transduce the signals into appropriate biological responses, including cell cycle arrest, induction of transcriptional programs, and modification or activation of repair factors. Here we show that the Saccharomyces cerevisiae Sae2 protein, known to be involved in processing meiotic and mitotic double-strand breaks, is required for proper recovery from...

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Source

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Identifiers

PMID: 15121837
DOI: 10.1128/MCB.24.10.4151-4165.2004
PMCID: PMC400471

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.PMID 15121837Read ↗

Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Semantic proximity Read ↗

Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling PathwaySemantic proximity Read ↗

CDK targets Sae2 to control DNA-end resection and homologous recombination.Semantic proximity Read ↗

Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.Semantic proximity Read ↗

Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.Semantic proximity Read ↗

Sae2p phosphorylation is crucial for cooperation with Mre11p for resection of DNA double-strand break ends during meiotic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Semantic proximity Read ↗

The yeast Xrs2 complex functions in S phase checkpoint regulation.Semantic proximity Read ↗

A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.Semantic proximity Read ↗

DNA Damage and Replication Stress CheckpointsSemantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment.Semantic proximity Read ↗

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