Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.

Developmental cell - 1 Oct 2001

Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz H R

Abstract excerpt

The C. elegans gene ced-12 functions in the engulfment of apoptotic cells and in cell migration, acting in a signaling pathway with ced-2 Crkll, ced-5 DOCK180, and ced-10 Rac GTPase and acting upstream of ced-10 Rac. ced-12 encodes a protein with a pleckstrin homology (PH) domain and an SH3 binding motif, both of which are important for ced-12 function. CED-12 acts in engulfing cells for cell corpse engulfment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Apoptosis Regulatory Proteins
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helminth Proteins

Share to Phagocytosis

Share to Proline

Share to rac GTP-Binding Proteins

Share to rho GTP-Binding Proteins

Source

Identifiers

PMID: 11703939
DOI: 10.1016/s1534-5807(01)00058-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.PMID 11703939Read ↗

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Semantic proximity Read ↗

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.Semantic proximity Read ↗

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that target different GTPasesSemantic proximity Read ↗

CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.Semantic proximity Read ↗

PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans.Semantic proximity Read ↗

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.Semantic proximity Read ↗

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.Semantic proximity Read ↗

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity.Semantic proximity Read ↗

RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.Semantic proximity Read ↗

The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions.Semantic proximity Read ↗

Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans.Semantic proximity Read ↗

Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.