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Article

Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.

Science (New York, N.Y.) - 5 Jul 1996

Hubbard E J, Dong Q, Greenwald I

Abstract excerpt

The Caenorhabditis elegans LIN-12 and GLP-1 proteins are members of the LIN-12/Notch family of receptors for intercellular signals that specify cell fate. Evidence presented here suggests that the intracellular domains of LIN-12 and GLP-1 interact with the C. elegans EMB-5 protein and that the emb-5 gene functions in the same pathway as the lin-12 and glp-1 genes. EMB-5 is similar in sequence to a yeast protein...

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PMID: 8658178
DOI: 10.1126/science.273.5271.112

Genes

EMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.PMID 8658178Read ↗

The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans.Semantic proximity Read ↗

SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.Semantic proximity Read ↗

EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans.Semantic proximity Read ↗

SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.Semantic proximity Read ↗

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Conservation of glp-1 regulation and function in nematodes.Semantic proximity Read ↗

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.Semantic proximity Read ↗

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.Semantic proximity Read ↗

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