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Article

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.

Nature structural & molecular biology - 1 Aug 2004

Lu Mingjian, Kinchen Jason M, Rossman Kent L, Grimsley Cynthia, deBakker Colin, Brugnera Enrico, Tosello-Trampont Annie-Carole, Haney Lisa B, Klingele Doris, Sondek John, Hengartner Michael O, Ravichandran Kodi S

Abstract excerpt

The members of the Dock180 superfamily of proteins are novel guanine nucleotide exchange factors (GEF) for Rho family GTPases and are linked to multiple biological processes from worms to mammals. ELMO is a critical regulator of Dock180, and the Dock180-ELMO complex functions as a bipartite GEF for Rac. We identified a mechanism wherein the PH domain of ELMO, by binding the Dock180-Rac complex in trans,...

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PMID: 15247908
DOI: 10.1038/nsmb800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PH domain of ELMO functions in trans to regulate Rac activation via Dock180.PMID 15247908Read ↗

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