Article
The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions.
PLoS genetics - 1 Jul 2016
Guan Liying, Ma Xuehua, Zhang Jingyan, Liu Jia-Jia, Wang Yingchun, Ding Mei
Abstract excerpt
Eukaryotic cells extend a variety of surface protrusions to direct cell motility. Formation of protrusions is mediated by coordinated actions between the plasma membrane and the underlying actin cytoskeleton. Here, we found that the single calponin homology (CH) domain-containing protein CHDP-1 induces the formation of cell protrusions in C. elegans. CHDP-1 is anchored to the cortex through its amphipathic helix....
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