Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.

PLoS genetics - 1 Jan 2012

Sun Lin, Liu Ou, Desai Jigar, Karbassi Farhad, Sylvain Marc-André, Shi Anbing, Zhou Zheng, Rocheleau Christian E, Grant Barth D

Abstract excerpt

Rac1 is a founding member of the Rho-GTPase family and a key regulator of membrane remodeling. In the context of apoptotic cell corpse engulfment, CED-10/Rac1 acts with its bipartite guanine nucleotide exchange factor, CED-5/Dock180-CED-12/ELMO, in an evolutionarily conserved pathway to promote phagocytosis. Here we show that in the context of the Caenorhabditis elegans intestinal epithelium CED-10/Rac1,...

Topics

Animals
Apoptosis Regulatory Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Carrier Proteins
Cell Membrane
Cytoskeletal Proteins
Endocytosis
Endosomes
GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Intestinal Mucosa

Membrane Proteins

Mutation

Phagocytosis

Protein Transport

Signal Transduction

Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22807685
DOI: 10.1371/journal.pgen.1002785
PMCID: PMC3395619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.PMID 22807685Read ↗

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Semantic proximity Read ↗

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.Semantic proximity Read ↗

LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes.Semantic proximity Read ↗

RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine.Semantic proximity Read ↗

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.Semantic proximity Read ↗

PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans.Semantic proximity Read ↗

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5.Semantic proximity Read ↗

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.Semantic proximity Read ↗

Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.Semantic proximity Read ↗

C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells.Semantic proximity Read ↗

C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.