Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.

PloS one - 1 Jan 2012

Lin Li, Tran Thuy, Hu Shuang, Cramer Todd, Komuniecki Richard, Steven Robert M

Abstract excerpt

RhoGEF proteins activate the Rho family of small GTPases and thus play a key role in regulating fundamental cellular processes such as cell morphology and polarity, cell cycle progression and gene transcription. We identified a Caenorhabditis elegans RhoGEF protein, RHGF-2, as a binding partner of the C. elegans multi-PDZ domain scaffold protein MPZ-1 (MUPP1 in mammals). RHGF-2 exhibits significant identity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Cell Shape

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Locomotion

Share to Nervous System

Share to PDZ Domains

Share to rho GTP-Binding Proteins

Share to Rho Guanine Nucleotide Exchange Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22363657
DOI: 10.1371/journal.pone.0031499
PMCID: PMC3282746

Genes

MPZ
RHO
PLEKHG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.PMID 22363657Read ↗

The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans.Semantic proximity Read ↗

Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans.Semantic proximity Read ↗

The Atypical Rho GTPase CHW-1 Works With SAX-3/Robo to Mediate Axon Guidance in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

A PDZ-RapGEF promotes synaptic development in Caenorhabditis elegans through a Rap/Rac signaling pathway.Semantic proximity Read ↗

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the <i>C. elegans</i> nervous systemSemantic proximity Read ↗

The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.Semantic proximity Read ↗

Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.Semantic proximity Read ↗

Rho family GTPases.Semantic proximity Read ↗

PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.Semantic proximity Read ↗

Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans.Semantic proximity Read ↗

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.