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Article

Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Yau Douglas M, Yokoyama Nobuhiko, Goshima Yoshio, Siddiqui Zeba K, Siddiqui Shahid S, Kozasa Tohru

Abstract excerpt

G alpha 12/13-mediated pathways have been shown to be involved in various fundamental cellular functions in mammalian cells such as axonal guidance, apoptosis, and chemotaxis. Here, we identified a homologue of Rho-guanine nucleotide exchange factor (GEF) in Caenorhabditis elegans (CeRhoGEF), which functions downstream of gpa-12, the C. elegans homologue of G alpha 12/13. CeRhoGEF contains a PSD-95/Dlg/ZO-1...

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PMID: 14657363
DOI: 10.1073/pnas.2533143100
PMCID: PMC299794

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PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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