Article

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that target different GTPases

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Coordinated activation and inhibition of F-actin supports the movements of morphogenesis. Understanding the proteins that regulate F-actin is important, since these proteins are mis-regulated in diseases like cancer. Our studies of C. elegans embryonic epidermal morphogenesis identified the GTPase CED-10/Rac1 as an essential activator of F-actin. However, we need to identify the GEF, or Guanine...

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Literature Corpus work: d251c84c-74c7-55df-8cdc-8ebe6aeddce0
DOI: 10.1101/2023.10.04.560868

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