Article
Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.
The Journal of clinical investigation - 1 Nov 2001
Burne M J, Daniels F, El Ghandour A, Mauiyyedi S, Colvin R B, O'Donnell M P, Rabb H
Abstract excerpt
Leukocytes have been implicated in the pathogenesis of ischemic acute renal failure (ARF), but the roles of the individual cell types involved are largely unknown. Recent indirect evidence suggests that T cells may play an important role in a murine model of ARF. In the current study, we found that mice deficient in T cells (nu/nu mice) are both functionally and structurally protected from postischemic renal...
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