Article
Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury.
American journal of physiology. Renal physiology - 1 Nov 2009
Jang Hye Ryoun, Gandolfo Maria Teresa, Ko Gang Jee, Satpute Shailesh, Racusen Lorraine, Rabb Hamid
Abstract excerpt
Kidney ischemia-reperfusion injury (IRI) is, in part, mediated by immune and inflammatory factors. Since microbial stimuli are known to alter immune and inflammatory responses, we hypothesized that differences in perinatal microbial status would modify renal injury following IRI. We performed bilateral renal IRI on 6-wk-old germ-free and control mice and studied the effects on kidney lymphocyte trafficking,...
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