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Article

Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury.

PloS one - 1 Jan 2008

Pulskens Wilco P, Teske Gwendoline J, Butter Loes M, Roelofs Joris J, van der Poll Tom, Florquin Sandrine, Leemans Jaklien C

Abstract excerpt

Toll-like receptors (TLRs) can detect endogenous danger molecules released upon tissue injury resulting in the induction of a proinflammatory response. One of the TLR family members, TLR4, is constitutively expressed at RNA level on renal epithelium and this expression is enhanced upon renal ischemia/reperfusion (I/R) injury. The functional relevance of this organ-specific upregulation remains however unknown. We...

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Source

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Identifiers

PMID: 18974879
DOI: 10.1371/journal.pone.0003596
PMCID: PMC2570789

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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