Article
Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury.
PloS one - 1 Jan 2008
Pulskens Wilco P, Teske Gwendoline J, Butter Loes M, Roelofs Joris J, van der Poll Tom, Florquin Sandrine, Leemans Jaklien C
Abstract excerpt
Toll-like receptors (TLRs) can detect endogenous danger molecules released upon tissue injury resulting in the induction of a proinflammatory response. One of the TLR family members, TLR4, is constitutively expressed at RNA level on renal epithelium and this expression is enhanced upon renal isch...
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