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Article

Double-negative T cells have a reparative role after experimental severe ischemic acute kidney injury.

American journal of physiology. Renal physiology - 1 Jun 2024

Lee Kyungho, Gharaie Sepideh, Kurzhagen Johanna T, Newman-Rivera Andrea M, Arend Lois J, Noel Sanjeev, Rabb Hamid

Abstract excerpt

T cells mediate organ injury and repair. A proportion of unconventional kidney T cells called double-negative (DN) T cells (TCR+ CD4- CD8-), with anti-inflammatory properties, were previously demonstrated to protect from early injury in moderate experimental acute kidney injury (AKI). However, their role in repair after AKI has not been studied. We hypothesized that DN T cells mediate repair after severe AKI....

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Source

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Identifiers

PMID: 38634135
DOI: 10.1152/ajprenal.00376.2023
PMCID: PMC11386976

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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