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Article

Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury.

American journal of physiology. Renal physiology - 1 Nov 2020

Mehrotra Purvi, Ullah Md Mahbub, Collett Jason A, Myers Sarah L, Dwinell Melinda R, Geurts Aron M, Basile David P

Abstract excerpt

To investigate T helper type 17 (Th17) cells in the setting of acute kidney injury, the gene encoding the master regulator of Th17 cell differentiation, that is, RAR-related orphan receptor-γ (RORγT), was mutated in Lewis rats using CRISPR/Cas9 technology. In response to 40 min of bilateral renal ischemia-reperfusion (I/R), RAR-related orphan receptor C (Rorc)-/- rats were resistant to injury relative to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32924545
DOI: 10.1152/ajprenal.00187.2020
PMCID: PMC7789982

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