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Article

Structural basis for recognition of the intron branch site RNA by splicing factor 1.

Science (New York, N.Y.) - 2 Nov 2001

Liu Z, Luyten I, Bottomley M J, Messias A C, Houngninou-Molango S, Sprangers R, Zanier K, Krämer A, Sattler M

Abstract excerpt

During spliceosome assembly, splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts. We show that the KH-QUA2 region of SF1 defines an enlarged KH (hn RNP K) fold which is necessary and sufficient for BPS binding. The 3' part of the BPS (UAAC), including the conserved branch point adenosine (underlined), is specifically recognized in a...

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Identifiers

PMID: 11691992
DOI: 10.1126/science.1064719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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