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Article

SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast.

Nucleic acids research - 5 May 2017

Carrocci Tucker J, Zoerner Douglas M, Paulson Joshua C, Hoskins Aaron A

Abstract excerpt

RNA and protein components of the spliceosome work together to identify the 5΄ splice site, the 3΄ splice site, and the branchsite (BS) of nascent pre-mRNA. SF3b1 plays a key role in recruiting the U2 snRNP to the BS. Mutations in human SF3b1 have been linked to many diseases such as myelodysplasia (MDS) and cancer. We have used SF3b1 mutations associated with MDS to interrogate the role of the yeast ortholog,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28062854
DOI: 10.1093/nar/gkw1349
PMCID: PMC5416834

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