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Article

Mechanism for cryptic splice site activation during pre-mRNA splicing.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Nelson K K, Green M R

Abstract excerpt

The 5' splice site of a pre-mRNA is recognized by U1 small nuclear ribonucleoprotein particles (snRNP) through base pairing with the 5' end of U1 small nuclear RNA (snRNA). Single-base substitutions within a 9-nucleotide 5'-splice-site sequence can abolish or attenuate use of that site and, in higher eukaryotes, can also activate nearby "cryptic" 5' splice sites. Here we show that the effects of single-base...

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Identifiers

PMID: 2143583
DOI: 10.1073/pnas.87.16.6253
PMCID: PMC54511

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Source receipt: pubmed, retrieved 7 Sept 2026.

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