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Article

Functional analysis of Hsh155/SF3b1 interactions with the U2 snRNA/branch site duplex.

RNA (New York, N.Y.) - 1 Aug 2018

Carrocci Tucker J, Paulson Joshua C, Hoskins Aaron A

Abstract excerpt

SF3b1 is an essential component of the U2 snRNP implicated in branch site (BS) recognition and found to be frequently mutated in several human cancers. While recent structures of yeast and human SF3b1 have revealed its molecular architecture, the importance of specific RNA:protein contacts and conformational changes remains largely uncharacterized. Here, we performed mutational analysis of yeast SF3b1, guided by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29752352
DOI: 10.1261/rna.065664.118
PMCID: PMC6049509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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