Kinectin is a key effector of RhoG microtubule-dependent cellular activity.

Abstract excerpt

RhoG is a member of the Rho family of GTPases that activates Rac1 and Cdc42 through a microtubule-dependent pathway. To gain understanding of RhoG downstream signaling, we performed a yeast two-hybrid screen from which we identified kinectin, a 156-kDa protein that binds in vitro to conventional kinesin and enhances microtubule-dependent kinesin ATPase activity. We show that RhoG(GTP) specifically interacts with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibodies, Blocking
• Share to cdc42 GTP-Binding Protein
• Share to Jurkat Cells