Article

SGEF coordinates epithelial morphogenesis by regulating junction stability, collective migration, and extracellular matrix remodeling

2026-07-20

Abstract excerpt

Polarized epithelia are essential for organ function, and disruption of epithelial polarity is a hallmark of many diseases, including cancer. We previously showed that the RhoG-specific guanine nucleotide exchange factor SGEF interacts with the Scribble polarity complex to regulate epithelial junction assembly in 2D monolayers. However, its role in epithelial morphogenesis and lumen formation in 3D remains unknown...

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Literature Corpus work: d8c5b131-6002-5d77-b8b0-a067485a71ed
DOI: 10.64898/2026.07.17.739205

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