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Article

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018

Shi Geng-Xian, Yang Won Seok, Jin Ling, Matter Michelle L, Ramos Joe W

Abstract excerpt

Directed migration is essential for cell motility in many processes, including development and cancer cell invasion. RSKs (p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood. We have identified a unique signaling mechanism by which RSK2 promotes cell motility through leukemia-associated RhoGEF...

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Identifiers

PMID: 29279389
DOI: 10.1073/pnas.1708584115
PMCID: PMC5777029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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