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Article

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.

Nature - 24 Jul 2003

Katoh Hironori, Negishi Manabu

Abstract excerpt

The small GTPase Rac has a central role in regulating the actin cytoskeleton during cell migration and axon guidance. Elmo has been identified as an upstream regulator of Rac1 that binds to and functionally cooperates with Dock180 (refs 2-4). Dock180 does not contain a conventional catalytic doma...

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PMID: 12879077
DOI: 10.1038/nature01817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12879077-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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