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Article

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.

The Journal of cell biology - 16 May 2011

Vega Francisco M, Fruhwirth Gilbert, Ng Tony, Ridley Anne J

Abstract excerpt

Several studies suggest that RhoA and RhoC, despite their sequence similarity, have different roles in cell migration and invasion, but the molecular basis for this is not known. Using RNAi, we show that RhoA-depleted cells became elongated and extended multiple Rac1-driven narrow protrusions in...

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Source

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Identifiers

PMID: 21576392
DOI: 10.1083/jcb.201011038
PMCID: PMC3166870

Genes

ROCK2
FMNL3
ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21576392-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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