Article
RacG regulates morphology, phagocytosis, and chemotaxis.
Eukaryotic cell - 1 Oct 2006
Somesh Baggavalli P, Vlahou Georgia, Iijima Miho, Insall Robert H, Devreotes Peter, Rivero Francisco
Abstract excerpt
RacG is an unusual member of the complex family of Rho GTPases in Dictyostelium. We have generated a knockout (KO) strain, as well as strains that overexpress wild-type (WT), constitutively active (V12), or dominant negative (N17) RacG. The protein is targeted to the plasma membrane, apparently in a nucleotide-dependent manner, and induces the formation of abundant actin-driven filopods. RacG is enriched at the...
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