Article
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.
Blood - 1 Jul 2008
Rondaij Mariska G, Bierings Ruben, van Agtmaal Ellen L, Gijzen Karina A, Sellink Erica, Kragt Astrid, Ferguson Stephen S G, Mertens Koen, Hannah Matthew J, van Mourik Jan A, Fernandez-Borja Mar, Voorberg Jan
Abstract excerpt
The small GTP-binding protein Ral has been implicated in regulated exocytosis via its interaction with the mammalian exocyst complex. We have previously demonstrated that Ral is involved in exocytosis of Weibel-Palade bodies (WPBs). Little is known about intracellular signaling pathways that promote activation of Ral in response to ligand binding of G protein-coupled receptors. Here we show that RNAi-mediated...
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