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Article

Expression Profile of RhoGTPases and RhoGEFs During RANKL-Stimulated Osteoclastogenesis: Identification of Essential Genes in Osteoclasts

30 Aug 2006

Abstract excerpt

UNLABELLED: RhoGTPases regulate actin cytoskeleton dynamics, a key element in osteoclast biology. We identified three novel genes induced during RANKL-stimulated osteoclastogenesis among RhoGTPases and their exchange factors that are essential in osteoclast biology. INTRODUCTION: During the process of differentiation, adhesion to the bone matrix or osteolysis, the actin cytoskeleton of osteoclasts undergoes...

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PMID: 16939397
DOI: 10.1359/jbmr.060613

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