Article

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

2018-06-24

Abstract excerpt

Rho GTPases control cell morphogenesis and thus fundamental processes in all eukaryotes. They are regulated by 145 RhoGEF and RhoGAP multi-domain proteins in humans. How the Rho signaling system is organized to generate localized responses in cells and prevent their spreading is not understood. Here, we systematically characterized the substrate specificities, localization and interactome of the RhoGEFs/RhoGAPs an...

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Literature Corpus work: 8420b824-cc24-5159-9663-c39a23a8870b
DOI: 10.1101/354316

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