Article

Total, not isoform-specific, Lyn expression by macrophages promotes TLR activation and restricts proliferation

2025-07-10

Abstract excerpt

Toll-like receptor (TLR) signaling is vital to antimicrobial macrophage function, and its dysregulation is associated with many disease states, including lupus, multiple sclerosis, pulmonary fibrosis, and cancer. The Src-family kinase Lyn plays activating and inhibitory roles downstream of TLRs, yet distinct functions of the Lyn splice variants LynA and LynB in TLR signaling had not been investigated. We used isof...

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Literature Corpus work: 4c02d8a4-3a3c-5592-b3ba-5a603d7f5883
DOI: 10.1101/2025.07.07.663098

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