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Article

Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.

Journal of autoimmunity - 1 Jun 2012

Maxwell Mhairi J, Tsantikos Evelyn, Kong Anne M, Vanhaesebroeck Bart, Tarlinton David M, Hibbs Margaret L

Abstract excerpt

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by the production of autoantibodies against nuclear components. Lyn-deficient mice are an excellent animal model of SLE manifesting clinical, pathological and biochemical features seen in the human disease. They develop autoreactive antibodies, glomerulonephritis and show generalized inflammation, and their B cells have a...

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Source

Identifiers

PMID: 22537464
DOI: 10.1016/j.jaut.2012.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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