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Article

Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.

1 May 1991

Abstract excerpt

cDNAs for the murine lyn protein tyrosine kinase gene were cloned from mouse bone marrow-derived monocytic cells. Comparison of the human and murine genes demonstrated a 94% homology in peptide sequence. Comparable to the human gene, murine lyn was found to be expressed in myeloid and B-lymphoid lineage cells. During the cloning, two types of cDNAs were obtained that differed by the presence (lynA) or absence...

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Identifiers

PMID: 2017160
DOI: 10.1128/mcb.11.5.2391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.PMID 2017160Read ↗

Splice-specific <i>lyn</i> knockout mice reveal a dominant function of LynB in preventing autoimmunitySemantic proximity Read ↗

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.Semantic proximity Read ↗

Total, not isoform-specific, Lyn expression by macrophages promotes TLR activation and restricts proliferationSemantic proximity Read ↗

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.Semantic proximity Read ↗

SH3 domains specifically regulate kinase activity of expressed Src family proteins.Semantic proximity Read ↗

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.Semantic proximity Read ↗

Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility.Semantic proximity Read ↗

Requirement of Src Kinase Lyn for Induction of DNA Synthesis by Granulocyte Colony-stimulating FactorSemantic proximity Read ↗

Association Between Imatinib-Resistant BCR-ABL Mutation-Negative Leukemia and Persistent Activation of LYN KinaseSemantic proximity Read ↗

Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties.Semantic proximity Read ↗

Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.Semantic proximity Read ↗

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.Semantic proximity Read ↗

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