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Article

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

Blood - 15 Jul 2001

O'Laughlin-Bunner B, Radosevic N, Taylor M L, Shivakrupa, DeBerry C, Metcalfe D D, Zhou M, Lowell C, Linnekin D

Abstract excerpt

Stem cell factor (SCF) binds to c-Kit and is an important mediator of survival, growth, and function of hematopoietic progenitor cells and mast cells. Lyn and other Src family members are activated by SCF and associate with phosphorylated tyrosine residues in the c-Kit juxtamembrane region. Howev...

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Source

Identifiers

PMID: 11435302
DOI: 10.1182/blood.v98.2.343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11435302-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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