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Article

Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1.

Genetic epidemiology - 1 Nov 2001

Valdes A M, Noble J A, Génin E, Clerget-Darpoux F, Erlich H A, Thomson G

Abstract excerpt

In this report, we present evidence that the HLA class II DPB1 locus (or a locus with alleles in linkage disequilibrium with DPB1) contributes to Type I diabetes (IDDM) susceptibility in addition to the contribution of the HLA DR and DQ loci. The marker association segregation chi-square (MASC) method, which fits both genotype frequency and affected sib-pair identity-by-descent (IBD) distributions, was applied to...

Topics

Alleles
Chi-Square Distribution
Diabetes Mellitus, Type 1
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DP Antigens
HLA-DP beta-Chains
Haplotypes
Humans
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11668578
DOI: 10.1002/gepi.1030

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Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1.PMID 11668578Read ↗

The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes.Semantic proximity Read ↗

The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.Semantic proximity Read ↗

HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families.Semantic proximity Read ↗

DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups.Semantic proximity Read ↗

HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.Semantic proximity Read ↗

Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus.Semantic proximity Read ↗

Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.Semantic proximity Read ↗

HLA-DPB1*0401 is associated with dominant protection against type 1 diabetes in the general Saudi population and in subjects with a high-risk DR/DQ haplotype.Semantic proximity Read ↗

HLA class II associations with Type 1 diabetes mellitus: a multivariate approach.Semantic proximity Read ↗

Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes.Semantic proximity Read ↗

HLA DPB1*0201 gene confers disease susceptibility in japanese with childhood onset type I diabetes, independent of HLA-DR and DQ genotypes.Semantic proximity Read ↗

HLA associations in insulin-dependent diabetes mellitus: no independent association to particular DP genes.Semantic proximity Read ↗

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