Article
The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.
Diabetes - 1 May 2001
Cucca F, Dudbridge F, Loddo M, Mulargia A P, Lampis R, Angius E, De Virgiliis S, Koeleman B P, Bain S C, Barnett A H, Gilchrist F, Cordell H, Welsh K, Todd J A
Abstract excerpt
The major histocompatibility complex (MHC) HLA region on chromosome 6p21 contains the major locus of type 1 diabetes (IDDM1). Common allelic variants at the class II HLA-DRB1, -DQA1, and -DQB1 loci account for the major part of IDDM1. Previous studies suggested that other MHC loci are likely to contribute to IDDM1, but determination of their relative contributions and identities is difficult because of strong...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Confidence Intervals
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Genetic Variation
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DQ Antigens