Article
HLA associations in type 1 diabetes: DPB1 alleles may act as markers of other HLA-complex susceptibility genes.
Tissue antigens - 1 May 2003
Johansson S, Lie B A, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Thorsby E, Undlien D E
Abstract excerpt
Alleles at the HLA-DQB1, -DQA1 and -DRB1 loci are major determinants for susceptibility to develop type 1 diabetes (T1D). Increasing evidence supports that also other genes in, or near, the HLA complex contribute to the HLA-encoded risk. Alleles at the DPB1 locus have been suggested to directly influence the risk conferred by DQB1, DQA1 and DRB1 alleles, but the results are conflicting. We therefore genotyped 217...
Topics
- Alleles
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Genotype
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Homozygote
- Humans