Article
Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus.
Human immunology - 1 May 2002
Rayner Michelle L, Kelly M Ann, Cordell Heather J, McTernan Claire L, Mijovic Catherine H, Barnett Anthony H
Abstract excerpt
The role of the DPB1 gene in genetic susceptibility to type I diabetes has yet to be elucidated. Studies of DPB1 alleles are conflicting. Analysis at the amino acid level, rather than consideration of allelic polymorphism, has been informative in determining disease susceptibility encoded by the DRB1 and DQ genes. In this study, therefore, amino acid variation at polymorphic sites of the DPbeta peptide chain...
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