Article
Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.
European journal of human genetics : EJHG - 1 Jan 1994
Zamani Ghabanbasani M, Spaepen M, Buyse I, Marynen P, Bex M, Bouillon R, Cassiman J J
Abstract excerpt
Polymorphisms in HLA class II genes have been shown to contribute to susceptibility or protection against insulin-dependent diabetes mellitus (IDDM). In the present study the role of HLA class II haplotypes and the role of DQ alpha Arg52, DQ beta Asp57 and of polymorphic amino acids, located in t...
Topics
- Adolescent
- Adult
- Alleles
- Amino Acids
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Infant
- Middle Aged
- Polymorphism, Genetic
- Risk Factors