Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.

European journal of human genetics : EJHG - 1 Jan 1994

Zamani Ghabanbasani M, Spaepen M, Buyse I, Marynen P, Bex M, Bouillon R, Cassiman J J

Abstract excerpt

Polymorphisms in HLA class II genes have been shown to contribute to susceptibility or protection against insulin-dependent diabetes mellitus (IDDM). In the present study the role of HLA class II haplotypes and the role of DQ alpha Arg52, DQ beta Asp57 and of polymorphic amino acids, located in the antigen-binding groove and the CD4-binding domain of the DR beta 1 chain, were studied in 210 unrelated Caucasian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Genotype

Share to Infant

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 7834277
DOI: 10.1159/000472361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.PMID 7834277Read ↗

Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals of different populations to type I diabetes.Semantic proximity Read ↗

HLA class II DR-DQ amino acids and insulin-dependent diabetes mellitus: application of the haplotype method.Semantic proximity Read ↗

Assessment of the DQB1-DQA1 complete genotype allows best prediction for IDDM.Semantic proximity Read ↗

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Semantic proximity Read ↗

Genetics of the HLA region in the prediction of type 1 diabetes.Semantic proximity Read ↗

Increased and decreased relative risk for non-insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles.Semantic proximity Read ↗

The combination of several polymorphic amino acid residues in the DQalpha and DQbeta chains forms a domain structure pattern and is associated with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

A new predictive model for insulin-dependent diabetes mellitus susceptibility based on combinations of molecular HLA-DRB1 and HLA-DQB1 pockets.Semantic proximity Read ↗

HLA-DQA1 and DQB1 gene polymorphisms in type I diabetic patients from central Italy and their use for risk prediction.Semantic proximity Read ↗

Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.Semantic proximity Read ↗

Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin-dependent) diabetes mellitus in a British Caucasian population.Semantic proximity Read ↗

Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.