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Article

Role of defective apoptosis in type 1 diabetes and other autoimmune diseases.

Recent progress in hormone research - 1 Jan 2003

Hayashi Takuma, Faustman Denise L

Abstract excerpt

Lymphocyte development, selection, and education are strictly controlled to prevent autoimmunity, with potentially autoreactive cells being removed by apoptosis. Dysregulation of apoptosis is a central defect in diverse murine autoimmune diseases. In murine models of autoimmune lupus, for example, mutations in the death receptor Fas (CD95) or in its ligand, FasL (CD95L), have been identified and shown to render...

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Identifiers

PMID: 12795417
DOI: 10.1210/rp.58.1.131

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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