Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas.

Experimental & molecular medicine - 30 Sept 2001

Nam D H, Song S Y, Park K, Kim M H, Suh Y L, Lee J I, Kim J S, Hong S C, Shin H J, Park K, Eoh W, Kim J H

Abstract excerpt

Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11 pituitary adenomas was graded by Hardy classification. We examined the retinoblastoma gene (RB1.20 on chromosome 13q) and the region around the MEN1 locus (chromosome 11q13.1-5) for loss of heterozygosity. Also examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 13

Share to Cyclin-Dependent Kinase Inhibitor p15

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Genes, Retinoblastoma

Share to Pituitary Neoplasms

Share to Radiography

Source

Identifiers

PMID: 11642545
DOI: 10.1038/emm.2001.20

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas.PMID 11642545Read ↗

Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker.Semantic proximity Read ↗

Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.Semantic proximity Read ↗

The p15<sup>INK4b</sup>/p16<sup>INK4a</sup>/RB1 Pathway Is Frequently Deregulated in Human Pituitary AdenomasSemantic proximity Read ↗

Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB.Semantic proximity Read ↗

Molecular pathogenesis of pituitary tumors.Semantic proximity Read ↗

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

Genetic basis of pituitary adenoma invasiveness: a review.Semantic proximity Read ↗

Cellular alterations in pituitary tumors.Semantic proximity Read ↗

11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.Semantic proximity Read ↗

p16 (INK4<sup><i>a</i></sup>, MTS‐1) gene polymorphism and methylation status in human pituitary tumoursSemantic proximity Read ↗

Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome.Semantic proximity Read ↗

Comparative genomic hybridization analysis of nonfunctioning pituitary tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.