Article
Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB.
Cancer research - 15 Apr 1995
Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict W F, Prager D
Abstract excerpt
Mice bearing retinoblastoma susceptibility gene (RB) germ-line mutations almost invariably develop pituitary neoplasms. We therefore tested 17 patients with pituitary tumors for loss of heterozygosity (LOH) using an RB sequence polymorphism and 5 polymorphic microsatellite markers surrounding the RB gene on the long arm of chromosome 13. In all of the 13 malignant or highly invasive pituitary tumor cases, and in...
Topics
- Alleles
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 13
- DNA Primers
- DNA, Satellite
- Exons
- Genes, Retinoblastoma
- Genes, Tumor Suppressor