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Article

p16 (INK4<sup><i>a</i></sup>, MTS‐1) gene polymorphism and methylation status in human pituitary tumours

1 Sept 1999

Abstract excerpt

OBJECTIVE: The p16 gene, which encodes a physiological inhibitor of the cyclin D-CDK4 complex, is now considered as an important tumour-suppressor gene in a variety of tumours. A marked reduction of its expression has been reported to occur without significant genetic alterations in human pituitary adenomas, although rare point mutations of uncertain functional significance have been described. On the other hand,...

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PMID: 10469011
DOI: 10.1046/j.1365-2265.1999.00774.x

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