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Article

The p15<sup>INK4b</sup>/p16<sup>INK4a</sup>/RB1 Pathway Is Frequently Deregulated in Human Pituitary Adenomas

1 May 2005

Abstract excerpt

Pituitary adenomas are common benign intracranial neoplasms. However, their tumorigenesis is not yet clearly defined. Inactivation of genes involved in the negative cell-cycle regulatory p15(INK4b) - p16(INK4a) -cyclin D/CDK4-RB1-mediated pathway (RB1 pathway) is one of the most common and important mechanisms in the growth advantage of tumor cells. Recently, much attention has been focused on the importance of...

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PMID: 15892297
DOI: 10.1093/jnen/64.5.398

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