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Article

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.

The Journal of clinical endocrinology and metabolism - 1 Aug 1998

Tanaka C, Kimura T, Yang P, Moritani M, Yamaoka T, Yamada S, Sano T, Yoshimoto K, Itakura M

Abstract excerpt

To investigate the role of tumor suppressor genes in sporadic pituitary adenomas, we first analyzed loss of heterozygosity on 11q13 with microsatellite analysis in 31 tumors. Loss of heterozygosity on 11q13 was detected in 1 mixed GH/PRL adenoma, and the somatic 22-bp deletion of the multiple endocrine neoplasia type 1 (MEN1) gene encoding menin was detected in this tumor. Trisomy 11 suggested by the decreased...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

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Share to In Situ Hybridization, Fluorescence

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Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 9709923
DOI: 10.1210/jcem.83.8.4888

Genes

MEN1
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.PMID 9709923Read ↗

Analysis of the MEN1 gene in sporadic pituitary adenomas.Semantic proximity Read ↗

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The MEN-1 gene is rarely down-regulated in pituitary adenomas.Semantic proximity Read ↗

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Molecular Characterization of the Men1 Tumor Suppressor Gene in Sporadic Pituitary TumorsSemantic proximity Read ↗

Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.Semantic proximity Read ↗

Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.Semantic proximity Read ↗

MEN1 gene analysis in sporadic adrenocortical neoplasms.Semantic proximity Read ↗

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.Semantic proximity Read ↗

Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.Semantic proximity Read ↗

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.Semantic proximity Read ↗

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