Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.

doi:10.1210/jcem.83.8.4888

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Article

Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas.

The Journal of clinical endocrinology and metabolism - 1 Aug 1998

Tanaka C, Kimura T, Yang P, Moritani M, Yamaoka T, Yamada S, Sano T, Yoshimoto K, Itakura M

Abstract excerpt

To investigate the role of tumor suppressor genes in sporadic pituitary adenomas, we first analyzed loss of heterozygosity on 11q13 with microsatellite analysis in 31 tumors. Loss of heterozygosity on 11q13 was detected in 1 mixed GH/PRL adenoma, and the somatic 22-bp deletion of the multiple end...

Topics

Adenoma
Alleles
Chromosomes, Human, Pair 11
Genes, Tumor Suppressor
Humans
In Situ Hybridization, Fluorescence
Loss of Heterozygosity
Microsatellite Repeats
Multiple Endocrine Neoplasia Type 1
Pituitary Neoplasms
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Trisomy

Source

Open in PubMed

Identifiers

PMID: 9709923
DOI: 10.1210/jcem.83.8.4888

Genes

MEN1
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9709923-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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