Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.

doi:10.1507/endocrj.50.309

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Article

Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.

Endocrine journal - 1 Jun 2003

Honda Soichi, Tanaka-Kosugi Chisato, Yamada Shozo, Sano Toshiaki, Matsumoto Toshio, Itakura Mitsuo, Yoshimoto Katsuhiko

Abstract excerpt

Components of cyclinD1/cyclin-dependent kinase 4 (CDK4)/p16INK4a/pRb pathway are the frequent target of many tumor types. We examined the role of retinoblastoma susceptibility gene (RB1) and the CDK4 gene in human pituitary tumorigenesis. For the RB1 gene, pRb expression and loss of heterozygosity (LOH) on 13q in pituitary adenomas were analysed. Immunostaining of pRb revealed lack of expression in 1 of 29...

Topics

Adenoma
Adult
Aged
Chromosomes, Human, Pair 13
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases
DNA Methylation
Female
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Male

Middle Aged

Mutation

Pituitary Neoplasms

Source

Open in PubMed

Identifiers

PMID: 12940460
DOI: 10.1507/endocrj.50.309

Genes

CDK4

Provenance

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