Article
Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker.
The Journal of clinical endocrinology and metabolism - 1 Mar 1997
Bates A S, Farrell W E, Bicknell E J, McNicol A M, Talbot A J, Broome J C, Perrett C W, Thakker R V, Clayton R N
Abstract excerpt
Tumors of the pituitary gland are usually benign adenomas and account for 10% of all intracranial neoplasms. Five pituitary tumors have previously been reported to harbor multiple allelic deletions. Of these, three displayed particularly aggressive biological behavior, whereas there were no clinical details provided for the others. This study was designed to test the hypothesis that genetic deletions are a marker...
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