Article
Activation of the RacGTPase inhibits apoptosis in human tumor cells.
Oncogene - 27 Sept 2001
Pervaiz S, Cao J, Chao O S, Chin Y Y, Clément M V
Abstract excerpt
The small GTP-binding protein Rac is a downstream effector of the oncogene product p21-ras. Rac is involved in actin polymerization, Jun kinase activation, and intracellular superoxide anion production, through distinct pathways in tumor cells. Here we investigated the role of activated Rac in the response of tumor cells to apoptosis triggered by anti-cancer drugs or the cell surface death receptor CD95. Using...
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