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Article

Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer.

Cancer gene therapy - 1 Feb 2011

Du J, Liu J, Smith B J, Tsao M S, Cullen J J

Abstract excerpt

K-ras mutations occur in as high as 95% of patients with pancreatic cancer. K-ras activates Rac1-dependent NADPH oxidase, a key source of superoxide. Superoxide has an important function in pancreatic cancer cell proliferation, and scavenging or decreasing the levels of superoxide inhibits pancre...

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Source

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Identifiers

PMID: 21037555
DOI: 10.1038/cgt.2010.64
PMCID: PMC3058504

Genes

MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21037555-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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