Article
A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014
Hornburger Michael C, Mayer Bettina A, Leonhardt Stefanie, Willer Elisabeth A, Zahler Stefan, Beyerle Andrea, Rajalingam Krishnaraj, Vollmar Angelika M, Fürst Robert
Abstract excerpt
Inhibitor of apoptosis (IAP) proteins, such as XIAP or cIAP1/2, are important regulators of apoptosis in cancer cells, and IAP antagonists are currently evaluated as antitumor agents. Beyond their function in cancer cells, this study demonstrates a novel role of IAPs as regulators of vascular endothelial permeability. Two structurally different IAP antagonists, ABT and Smac085, as well as silencing of IAPs,...
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